Copper-catalyzed cascade reactions of α,β-unsaturated esters with keto esters

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Copper-catalyzed cascade reactions of α,β-unsaturated esters with keto esters

A copper-catalyzed cascade reaction of α,β-unsaturated esters with keto esters is reported. It features a copper-catalyzed reductive aldolization followed by a lactonization. This method provides a facile approach to prepare γ-carboxymethyl-γ-lactones and δ-carboxymethyl-δ-lactones under mild reaction conditions.

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ژورنال

عنوان ژورنال: Beilstein Journal of Organic Chemistry

سال: 2015

ISSN: 1860-5397

DOI: 10.3762/bjoc.11.23